Protein Modification Reagents
Worthington Biochemical Corporation ELASTASE SUSPENSION 1GM
Two times crystallized. Supplied as an aqueous suspension. This preparation must be diluted to dissolve the enzyme. The diluted enzyme should be 0.22 micron filtered before use. Suitable for the isolation of Type II lung cells. 2594-83-7
Medchemexpress LLC 5,8,11,14-tetraoxa-2-azahexadecanedioic acid, 1-(1,1-dimethylethyl) ester | 876345-13-0 | MFCD30528568 | ≥97.0% | 351.39 g/mol | C15H29NO8 | 1 G
Boc-NH-PEG4-CH2COOH is a Boc-protected polyethylene glycol (PEG4) linker terminating in a carboxylic acid, used as a cleavable linker in conjugation chemistry and in the synthesis of PROTACs and antibody-drug conjugates.
- Cleavable Boc-protected PEG4 linker suitable for conjugation chemistry.
- Terminal carboxylic acid compatible with amide coupling reactions.
- High purity (≥97.0%) and molecular weight 351.39 g/mol.
- Available as a 1 g unit; other pack sizes are offered for synthetic applications.
- Store pure material at -20°C; stability in solvent is limited and temperature dependent.
Medchemexpress LLC FAK ligand-Linker Conjugate 1 | 2307461-45-4 | 98.9% | 583.58 | 5 MG
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK and a PROTAC linker, which recruits E3 ligases (such as VHL, CRBN, MDM2, and IAP). It can be extensively used for PROTAC-mediated protein degradation.
- Purity: 98.91%
- Appearance: Solid
- Color: White to off-white
- Solubility: In Vitro: DMSO : 100 mg/mL (171.36 mM; Needs ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of the product, so newly opened DMSO should be used).
- Storage: Powder: -20°C for 3 years, 4°C for 2 years. In solvent: -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC DSPE-PEG-maleimide (ammonium) | 3,400 Da | 10 MG
DSPE-PEG-Maleimide (MW 3400) ammonium is a phospholipid-polyethylene glycol conjugate bearing a maleimide functional group for thiol-specific coupling. It is designed for incorporation into lipid-based delivery systems to enable surface modification and bioconjugation while providing steric stabilization from the PEG chain.
- Provides a thiol-reactive maleimide functional group for covalent coupling.
- Contains a DSPE lipid tail for stable incorporation into lipid bilayers.
- Has a PEG spacer (~3,400 Da) to improve steric stabilization and circulation time.
- Suitable for preparing PEGylated liposomes, micelles, and nanostructured lipid carriers.
- Enables surface conjugation of peptides, antibodies, or small thiol-containing ligands.
Medchemexpress LLC Dbco-peg5-nhs ester | 2144395-59-3 | 95.1% | 693.74 | C36H43N3O11 | 100 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used for copper-free click conjugation of azide-containing molecules to primary amines. It functions as a PEG-based linker for bioconjugation and linker chemistry, and is supplied as an oil with defined purity and solubility properties.
- Enables copper-free click conjugation to azide-containing molecules.
- Reacts with primary amines via NHS ester chemistry.
- Provides a PEG5 spacer to reduce steric hindrance and improve solubility.
- High purity suitable for bioconjugation (HPLC ~95%).
- Soluble in DMSO at 100 mg/mL with ultrasonic or warming aid.
- Store solid at -20°C and prepared solutions at -80°C for long-term storage.
Medchemexpress LLC DBCO-PEG2-acid | 2304558-25-4 | ≥95.0% | C26H28N2O6 | 250 MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for synthesizing PROTACs. It acts as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs typically comprise two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets the protein of interest, enabling selective degradation through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Incorporates a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Suitable for laboratory chemical applications
Medchemexpress LLC Bromo-PEG4-azide | 1951439-37-4 | 98.1% | C10H20BrN3O4 | 250 MG
Bromo-PEG4-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC Mal-amido-PEG12-NHS ester | 2101722-60-3 | 98.52% | C38H63N3O19 | 25 MG
Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | MFCD01346226 | 100.0% | 1083.12 | C54H63FN8O15 | 10 MG
Propargyl-PEG4-GGFG-DXd is a pre-formed drug-linker conjugate intended for research use in antibody-drug conjugate (ADC) development. It combines a PEG4-linked GGFG tetrapeptide linker with a DXd topoisomerase I inhibitor payload to support linker evaluation and conjugation workflows.
- Contains a DXd topoisomerase I inhibitor payload.
- Includes a PEG4 spacer and GGFG tetrapeptide linker for conjugation.
- Off-white to light yellow solid, high purity suitable for analytical work.
- Soluble in DMSO at up to 100 mg/mL with ultrasonic assistance.
- Stable when stored sealed and protected from moisture; in solvent: -80 °C (6 months), -20 °C (1 month).
Medchemexpress LLC NHS-PEG1-SS-PEG1-NHS | 1688598-83-5 | 98.0% | 436.41 | 50 MG
NHS-PEG1-SS-PEG1-NHS is a reversible linker designed for conjugating biomacromolecules with active small molecules.
- Reversible linker
- Designed for conjugating biomacromolecules with active small molecules
- Suitable for use in proteins
- Suitable for use in liposomes
- Suitable for use in nanoparticles
Medchemexpress LLC Cholesterol-PEG 600 | 69068-97-9 | 1,055.60 g/mol | C68H110O8 | 1 G
Cholesterol-PEG 600 is a cholesterol-terminated polyethylene glycol reagent (average PEG MW ~600) used in life-science research to modify lipid assemblies and improve amphiphilic conjugation. It is supplied as an oil (off-white to light yellow) for formulation into liposomes, nanoparticles, and other delivery systems. For research use only.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum, 9001-12-1, MFCD00130830, 100 mg
For general use, Type I, 0.25-1.0 FALGPA units/mg solid, ≥125 CDU/mg solid, Synonym: Clostridiopeptidase A. Collagenase from Clostridium histolyticum has extensive use in biological studies, where it is used to prepare isolated cell suspensions. This product is suitable for the disaggregation of human tumor, mouse kidney, human adult and fetal brain, lung and many other epithelia tissues.